The present study continues our previous efforts to explore the roles played by white matter in initiating diseases. In this study, we explored the ageing of white matter from different points of views including gender, age, histology, genetic and biomarkers involved in its ageing. We also explored the involvement of white matter ageing in some neurodegenerative diseases including Alzheimer Disease. Due to the important roles of white matter in initiating diseases, it is important to take appropriate measures to concentrate on this topic by scientific communities and to probably design some programs to detect cases at an early stage, particularly because the ageing of white matter precedes the clinical onset of diseases. Taken together, white matter ageing is an important topic for future intervention programs.