Background: Gliomas, derived from Glial cells, constitute 80% of malignant brain tumors. Quantum dots (QDs), with distinct optical and electronic attributes, have emerged as potential therapeutic agents for gliomas. This review evaluates the current research landscape of QD applications for glioma treatment.

Materials and Methods: A rigorous literature search spanned key databases: PubMed, Scopus, and Web of Science. Selection utilized the ASReview Algorithm, an innovative machine learning framework, compliant with PRISMA guidelines.

Results: From 170 initial studies, 16 were discerningly chosen, highlighting the synthesis, properties, and therapeutic roles of QDs. Emphasis was placed on QDs' proficiency in drug delivery, imaging enhancement, and photodynamic therapy. Research underscored QDs' potential in cancer cell eradication via phototherapy and enhanced glioma imaging.

Conclusion: QDs offer a promising strategy for treating refractory gliomas. However, concerns about their toxicity and stability persist. Future studies must address these issues to optimize QD utilization in glioma management. This review furnishes critical insights, steering future research directions in QD-focused oncology.