Study states the lipoprotein lipase and hepatic lipase gene polymorphism may be associated in cardio vascular disease. Thus our aim was to evaluate the frequency of LPL and HL polymorphism in Indian sickle cell patients and their clinical outcomes. We had evaluated 162 sickle patients and 170 controls to compare the frequency. Study reported the similar frequency amongst patients and controls. Their was no clinical association of these gene variant and cardiac risk factor in sickle patients.