Endocarditis affecting the right side of the heart is a distinct clinical condition, albeit less common than its left-side counterpart. Managing infective endocarditis in pediatric patients poses various challenges, particularly when congenital heart disease, often associated with increased risk, is present. While a history of congenital heart disease remains the predominant risk factor, new predisposing conditions are gaining significance. In this case report, we detail the clinical manifestation, diagnostic process, and treatment of isolated native pulmonary valve endocarditis in a pediatric patient who underwent surgical intervention for Tetralogy of Fallot a year prior.